Description

1-β-D-Arabinofuranosylcytosine Hydrochloride is a nucleoside analog and the hydrochloride salt of Cytarabine, a critical active pharmaceutical ingredient (API). This compound serves as a fundamental building block in the synthesis of antiviral and anticancer pharmaceuticals, where consistent high purity is paramount for efficacy and safety. It is essential for manufacturers in the pharmaceutical and biotechnology sectors engaged in the development and production of chemotherapeutic agents and antiviral medications.

Application

• Primary Active Pharmaceutical Ingredient (API): The core component in the formulation of Cytarabine injectable drugs for chemotherapy.
• Anticancer Drug Synthesis: A key intermediate in the manufacture of chemotherapeutic agents used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and other cancers.
• Antiviral Research & Development: Used in the synthesis of nucleoside analogs for antiviral therapies targeting herpesviruses and other viral infections.
• Biochemical Research: Employed as a standard or reagent in oncology and molecular biology research to study DNA synthesis inhibition and cell cycle effects.
• Pharmaceutical Intermediates: Serves as a critical starting material or intermediate in multi-step synthetic routes for novel therapeutic compounds.

Basic Information

Product Name	1-β-D-Arabinofuranosylcytosine Hydrochloride
CAS No.	69-74-9
Molecular Formula	C9H14ClN3O5
Molecular Weight	279.68 g/mol
Synonyms	Cytarabine Hydrochloride; Cytosine Arabinoside Hydrochloride; Ara-C Hydrochloride; 1-β-D-Arabinofuranosylcytosine Hydrochloride; 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone Hydrochloride; Cytosar-U (as API); β-Cytosine Arabinoside HCl
EINECS	200-721-7

Quality Control

Our 1-β-D-Arabinofuranosylcytosine Hydrochloride is manufactured and tested under strict quality systems suitable for pharmaceutical applications. Quality assurance includes comprehensive testing against established pharmacopeial standards (such as USP/EP) for identity, purity, and potency. A detailed Certificate of Analysis (COA) is provided with each batch, ensuring full traceability and compliance with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Specific Rotation	+154° to +160° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.