Description

(2-Pyridyldithio)-Peg4 Acid is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a reactive pyridyldithiol group and a carboxylic acid terminus. This compound is essential for creating stable, cleavable conjugates in bioconjugation and drug delivery applications, as the disulfide bond provides a mechanism for controlled release under reducing conditions. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, antibody-drug conjugate (ADC) production, and advanced material science for modifying proteins, peptides, and nanoparticles.

Application

• Antibody-Drug Conjugate (ADC) Linker: Used to covalently attach cytotoxic payloads to monoclonal antibodies via cleavable disulfide bonds.
• Protein and Peptide Modification: Enables site-specific PEGylation to improve pharmacokinetics, solubility, and stability of therapeutic biomolecules.
• Surface Functionalization: For immobilizing biomolecules onto sensors, chips, or nanoparticles for diagnostic and research applications.
• Controlled Release Systems: Serves as a key component in the design of drug delivery vehicles where payload release is triggered by intracellular glutathione.
• Crosslinking Agent: Used in the synthesis of hydrogels and polymer networks with tailored degradation profiles.
• Bioconjugation Reagent: Facilitates the formation of stable thioether bonds between thiol-containing molecules and primary amines after activation of the carboxylic acid group.

Basic Information

Product Name	(2-Pyridyldithio)-Peg4 Acid
CAS No.	581065-93-2
Molecular Formula	C₂₁H₃₂N₂O₈S₂
Molecular Weight	504.61 g/mol
Synonyms	2-Pyridyldithio tetraethyleneglycol acetic acid; PDP-PEG4-COOH; SS-PEG4-COOH; 17-({2-[(2-{2-[2-(2-Pyridinyldithio)ethoxy]ethoxy}ethoxy)ethoxy]acetyl}amino)-4,7,10,13-tetraoxa-16-azaheptadecanoic acid; α-(2-Pyridyldithio)-ω-carboxy tetraethylene glycol; SPPA-PEG4; Heterobifunctional PEG crosslinker, PDP-PEG4-Acid; Pyridyl disulfide PEG4 acid
EINECS	Contact for details

Quality Control

Our (2-Pyridyldithio)-Peg4 Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for sensitive bioconjugation work. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.