Description

Orvepitant Maleate is a high-purity, non-peptide neurokinin-1 (NK1) receptor antagonist with significant pharmacological research and development applications. Its primary value lies in its potent and selective antagonism, making it a critical reference standard and active pharmaceutical ingredient (API) for preclinical and clinical studies targeting conditions like chemotherapy-induced nausea and vomiting (CINV) and depression. This compound is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in neurokinin pathway research and novel therapeutic development.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in API and finished product testing.
• Preclinical Research: Serves as a key pharmacological tool for in vitro and in vivo studies investigating the role of the NK1 receptor in emesis, mood disorders, and pain pathways.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the synthesis and formulation development of potential therapeutic agents targeting the NK1 receptor.
• Clinical Trial Material: Supplied under current Good Manufacturing Practice (cGMP) conditions for use in formulating investigational medicinal products for human clinical trials.
• Biochemical Assay Development: Utilized in high-throughput screening (HTS) and binding assays to discover and characterize new NK1 receptor modulators.

Basic Information

Product Name	Orvepitant Maleate
CAS No.	579475-24-4
Molecular Formula	C33H35N5O6
Molecular Weight	597.67 g/mol
Synonyms	(2R,4S)-2-(1H-Benzimidazol-2-yl)-1-[(3,5-bis(trifluoromethyl)benzyl)oxy]-4-(4-fluorophenyl)-6-(4-methylpiperazin-1-yl)methyl]morpholine maleate; Orvepitant hydrogen maleate; GW597599; GW-597599
EINECS	Contact for details

Quality Control

Our Orvepitant Maleate is manufactured and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting specifications suitable for research and development use. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment. We support development from research to clinical stages with appropriate quality documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.