Description

Orvepitant CAS NO 579475-18-6 is a high-purity, non-peptide neurokinin-1 (NK1) receptor antagonist. This compound is a critical advanced intermediate and reference standard in pharmaceutical research and development, valued for its specific biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for central nervous system disorders, emesis, and pain management.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control in drug substance and product testing.
• Drug Discovery & Development: Used as a key intermediate or active pharmacophore in the synthesis and optimization of new NK1 receptor antagonist candidates.
• Neuroscience Research: Employed in in vitro and in vivo studies to investigate the role of Substance P and NK1 receptors in various physiological and pathological processes.
• Preclinical Studies: Utilized in animal models to evaluate the efficacy and pharmacokinetics of potential antiemetic, antidepressant, and analgesic agents.
• Biochemical Assay Development: Acts as a tool compound for screening assays and binding studies to identify and characterize new NK1 receptor ligands.

Basic Information

Product Name	Orvepitant
CAS No.	579475-18-6
Molecular Formula	C₂₃H₂₅FN₄O₂
Molecular Weight	408.47 g/mol
Synonyms	5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; GW597599; GW-597599; Orvepitant maleate (salt form)
EINECS	Contact for details

Quality Control

Our Orvepitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent determination, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) confirming identity, purity, and specification is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.