Description

6-Fmoc-Amino-D-Luciferin is a chemically modified derivative of D-luciferin, a critical substrate for bioluminescence. This compound is specifically engineered for solid-phase peptide synthesis (SPPS), where the Fmoc (9-fluorenylmethoxycarbonyl) protecting group provides orthogonal protection for the amino functionality. It is essential for researchers and manufacturers developing bioluminescent probes, biosensors, and assay kits that require site-specific conjugation of luciferin to peptides or proteins. The product, identified by CAS No. 578705-47-2, serves advanced applications in pharmaceutical research, molecular diagnostics, and high-throughput screening.

Application

• Solid-Phase Peptide Synthesis (SPPS): Key building block for the controlled incorporation of luciferin into synthetic peptides, enabling the creation of bioluminescent peptide conjugates.
• Bioluminescent Probe Development: Used to synthesize targeted probes for molecular imaging, allowing real-time visualization of biological processes in vitro and in vivo.
• Biosensor Fabrication: Essential for constructing sensitive assay platforms and diagnostic devices that utilize luciferase-based detection systems.
• High-Throughput Screening (HTS) Assays: Enables the development of cell-based and biochemical assays for drug discovery, where bioluminescence serves as a highly sensitive readout.
• Protein Labeling and Tagging: Facilitates site-specific labeling of proteins with a bioluminescent tag for studies on protein-protein interactions, localization, and turnover.
• Research Reagent for Chemical Biology: A critical tool for academic and industrial research exploring novel bioluminescence applications and signal transduction pathways.

Basic Information

Product Name	6-Fmoc-Amino-D-Luciferin
CAS No.	578705-47-2
Molecular Formula	C30H24N2O6S2
Molecular Weight	572.65 g/mol
Synonyms	6-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-D-luciferin; D-Luciferin, 6-[(9H-fluoren-9-ylmethoxy)carbonyl]amino-; 6-(Fmoc-amino)-D-luciferin; Fmoc-Luciferin; 6-Fmoc-Amino-D-Luciferin; 6-Fmoc-Amino-D-Luciferin, Fmoc-protected; (4S)-4,5-Dihydro-2-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-1,3-benzothiazol-2-yl)-4-thiazolecarboxylic acid
EINECS	Contact for details

Quality Control

Our 6-Fmoc-Amino-D-Luciferin is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic identification (NMR, MS). Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area Percent)
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.