Description

7-Methyl Wyosine is a modified nucleoside derivative, specifically a hypermodified guanosine analog found in transfer RNA (tRNA). This compound is of significant interest in biochemical research and pharmaceutical development due to its role in tRNA structure and function. It serves as a critical reference standard and building block for researchers in nucleic acid chemistry, molecular biology, and drug discovery, particularly for studies involving tRNA modification, stability, and translational fidelity.

Application

• Biochemical Research Standard: Used as a high-purity reference standard for the identification and quantification of wyosine derivatives in tRNA analysis.
• Nucleic Acid Chemistry: Serves as a specialized monomer or intermediate in the synthesis of modified oligonucleotides for structural and functional studies.
• Enzymology Studies: Employed as a substrate or inhibitor to study tRNA-modifying enzymes, such as methyltransferases.
• Pharmaceutical R&D: Investigated for its potential role in developing novel therapeutics targeting translation or specific RNA pathways.
• Diagnostic Development: Potential use in developing assays to detect specific tRNA modifications linked to disease states.
• Academic Research: Essential for fundamental research into the post-transcriptional modification of RNA and its biological consequences.

Basic Information

Product Name	7-Methyl Wyosine
CAS No.	577773-09-2
Molecular Formula	C17H23N5O5
Molecular Weight	377.40 g/mol
Synonyms	7-Methylwyosine; N7-Methylwyosine; 1-Methyl-4-demethylwyosine; 7-Methyl-4-demethylwyosine; 7-Methyl-3-(β-D-ribofuranosyl)-3,9-dihydro-4H-imidazo[1,2-a]purin-4-one; 3-(β-D-Ribofuranosyl)-7-methyl-3,9-dihydro-4H-imidazo[1,2-a]purin-4-one; tRNA Nucleoside Y Derivative
EINECS	Contact for details

Quality Control

Our 7-Methyl Wyosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the exacting standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.