Description

2,6-Dimethyl-4-Quinolinecarboxylic Acid n-Hydroxysuccinimide Ester is a high-purity, reactive chemical intermediate designed for advanced synthesis. This compound is a critical building block for the formation of stable amide bonds, enabling the precise conjugation of quinoline derivatives to target molecules. It is primarily utilized by research institutions and pharmaceutical developers working on novel drug discovery, diagnostic agents, and advanced material science projects.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs containing quinoline scaffolds.
• Bioconjugation & Labeling: Used for coupling quinoline-based fluorophores, tags, or therapeutic payloads to antibodies, proteins, peptides, and other biomolecules.
• Diagnostic Probe Development: Essential for creating fluorescent or chemiluminescent probes for cellular imaging, immunoassays, and biosensors.
• Material Science Research: Serves as a functionalization agent for modifying polymer surfaces or nanoparticles with quinoline moieties.
• Chemical Biology: Employed in activity-based protein profiling (ABPP) and the development of covalent inhibitors.
• Organic Synthesis: A versatile N-hydroxysuccinimide (NHS) ester for efficient amide bond formation under mild conditions in complex molecule assembly.

Basic Information

Item	Details
Product Name	2,6-Dimethyl-4-Quinolinecarboxylic Acid n-Hydroxysuccinimide Ester
CAS No.	569355-30-2
Molecular Formula	C16H16N2O4
Molecular Weight	300.31 g/mol
Synonyms	2,6-Dimethylquinoline-4-carboxylic acid N-succinimidyl ester; 2,6-Dimethyl-4-quinolinecarboxylic acid N-hydroxysuccinimide ester; 4-Quinolinecarboxylic acid, 2,6-dimethyl-, 1,2,3,6-tetrahydro-2,5-dioxo-1H-pyrrol-1-yl ester; 2,6-Dimethylquinoline-4-carbonyloxy succinimide; NHS ester of 2,6-dimethylquinoline-4-carboxylic acid; 2,6-Dimethyl-4-quinolinecarbonyloxysuccinimide; 569355-30-2 (CAS); DMQ-NHS Ester
EINECS	Contact for details

Quality Control

Every batch of 2,6-Dimethyl-4-Quinolinecarboxylic Acid n-Hydroxysuccinimide Ester is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) providing detailed results for purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions, preferably with desiccant, to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; sparingly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.