Description

Rolapitant (1R,2S,3R)-Isomer CAS NO 552292-73-6 is a specific stereoisomer of the potent and selective neurokinin-1 (NK1) receptor antagonist, Rolapitant. This high-purity intermediate is critical for the synthesis of the active pharmaceutical ingredient (API) used in antiemetic medications. It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities for the development and production of therapeutics to prevent chemotherapy-induced nausea and vomiting (CINV).

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of the Rolapitant API.
• Antiemetic Drug Development: Used in research and manufacturing of drugs targeting the NK1 receptor for CINV prevention.
• Clinical Trial Material: Sourced for the production of batches used in clinical studies and regulatory submissions.
• Process Chemistry & Scale-Up: Essential for process optimization and commercial-scale manufacturing of the final drug substance.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation.

Basic Information

Product Name	Rolapitant (1R,2S,3R)-Isomer
CAS No.	552292-73-6
Molecular Formula	C25H27FNO4
Molecular Weight	424.49 g/mol
Synonyms	(1R,2S,3R)-5-[(5,7-Difluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-N-methyl-4-piperidinecarboxamide; Rolapitant Isomer; SCH 619734 Isomer; (1R,2S,3R)-Isomer of Rolapitant; Varubi Intermediate; NK1 Receptor Antagonist Intermediate
EINECS	Contact for details

Quality Control

Our Rolapitant (1R,2S,3R)-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for stereochemical purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.