Description

7S,8R,17R-Trihydroxy-4Z,9E,11E,13Z,15E19Z-Docosahexaenoic Acid is a specialized, highly oxygenated metabolite of docosahexaenoic acid (DHA), representing a key bioactive lipid mediator in specialized pro-resolving mediator (SPM) pathways. This compound matters for its potent role in modulating inflammatory responses and promoting the resolution of inflammation without immunosuppression. It is primarily needed by researchers in pharmaceutical development, nutraceutical formulation, and advanced biomedical research focusing on chronic inflammatory conditions, metabolic disorders, and immune modulation.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical method development, validation, and quality control in drug discovery and development.
• Biomedical Research: Critical for in vitro and in vivo studies investigating the mechanisms of inflammation resolution, immune cell function, and tissue repair processes.
• Nutraceutical R&D: Serves as a key ingredient or biomarker in the development of advanced anti-inflammatory and pro-resolving dietary supplements and functional foods.
• Metabolomics & Lipidomics: An essential standard for the identification and quantification of SPMs in complex biological samples using LC-MS/MS and other analytical platforms.
• Preclinical Drug Candidate: Investigated for therapeutic potential in models of chronic inflammatory diseases, including arthritis, atherosclerosis, and neurodegenerative conditions.
• Cosmeceutical Actives: Explored for topical formulations aimed at reducing skin inflammation and promoting healing due to its pro-resolving properties.

Basic Information

Product Name	7S,8R,17R-Trihydroxy-4Z,9E,11E,13Z,15E19Z-Docosahexaenoic Acid
CAS No.	528583-91-7
Molecular Formula	C22H32O5
Molecular Weight	376.49 g/mol
Synonyms	RvD1 (Resolvin D1); 7S,8R,17R-Trihydroxydocosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic Acid; Resolvin D1; Aspirin-triggered Resolvin D1 isomer; AT-RvD1; 7(S),8(R),17(R)-Resolvin D1; Protectin D1 isomer; Specialized Pro-resolving Mediator (SPM) D1.
EINECS	Contact for details

Quality Control

Our 7S,8R,17R-Trihydroxy-4Z,9E,11E,13Z,15E19Z-Docosahexaenoic Acid is produced and controlled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its sensitivity to oxidation and moisture. Allow the sealed container to reach room temperature before opening to minimize condensation and exposure to air.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.