Description

Boc-Gly-Amido-(Ch2)3-Peg3-(Ch2)3-Amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a Boc-protected amine on one terminus and a glycine amide group on the other. This compound is specifically engineered to provide a hydrophilic, flexible spacer for bioconjugation and cross-linking applications in advanced research and development. It is a critical reagent for pharmaceutical and biotech companies engaged in the synthesis of peptide-drug conjugates, antibody-drug conjugates (ADCs), and other complex biomolecules. The CAS number for this compound is 525583-49-7.

Application

• Bioconjugation and Cross-linking: Serves as a versatile linker for connecting peptides, proteins, or antibodies to drugs, fluorophores, or solid surfaces.
• Antibody-Drug Conjugate (ADC) Development: Used to create stable, cleavable linkers that attach cytotoxic payloads to monoclonal antibodies, enhancing therapeutic efficacy and solubility.
• Peptide Synthesis and Modification: Facilitates the site-specific introduction of functional groups or PEG chains into peptide sequences to improve pharmacokinetic properties.
• Drug Delivery System Fabrication: Incorporated into nanoparticles, liposomes, and polymer-drug conjugates to enhance solubility, reduce immunogenicity, and prolong circulation time.
• Proteomics and Biomaterial Research: Employed to functionalize surfaces for biosensors, microarrays, and tissue engineering scaffolds.
• Diagnostic Reagent Preparation: Used in the synthesis of contrast agents or labeled probes for imaging and diagnostic assays.

Basic Information

Product Name	Boc-Gly-Amido-(Ch2)3-Peg3-(Ch2)3-Amine
CAS No.	525583-49-7
Molecular Formula	C24H47N3O9
Molecular Weight	521.65 g/mol
Synonyms	Boc-NH-PEG3-C3-Amine; tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate; 1-Amino-3,6,9-trioxa-12-azatetradecan-14-oic acid, 14-[(1,1-dimethylethoxy)carbonyl]-, 1-amide; Boc-15-amino-4,7,10,13-tetraoxapentadecanoic acid; Boc-N-amido-PEG3-C3-amine; Heterobifunctional PEG linker, Boc-amine; (Boc-amino)-PEG3-C3-amine; PEG-based Boc-protected amine linker
EINECS	Contact for details

Quality Control

Every batch of Boc-Gly-Amido-(Ch2)3-Peg3-(Ch2)3-Amine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our products are suitable for research and development applications, with quality standards that support pre-clinical studies. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Long-term storage is recommended at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.