Description

Mal-Peg4-Acid CAS NO 518044-41-2 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group at one terminus and a carboxylic acid at the other, separated by a tetraethylene glycol spacer. This compound is a critical reagent in bioconjugation chemistry, enabling the site-specific coupling of thiol-containing molecules (like peptides, proteins, or antibodies) to amine-containing surfaces or molecules via its acid group. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science who require precise and stable linkages for creating antibody-drug conjugates (ADCs), PEGylated therapeutics, diagnostic assays, and functionalized hydrogels.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via cysteine residues.
• Protein and Peptide PEGylation: Modification of therapeutic proteins to enhance solubility, stability, and circulation half-life.
• Surface Functionalization: Immobilization of thiolated biomolecules (e.g., peptides, oligonucleotides) onto amine-coated biosensor chips, microarrays, or nanoparticles.
• Crosslinking Agent: Formation of hydrogels or polymer networks by reacting with both thiol and amine-functionalized macromolecules.
• Diagnostic Reagent Synthesis: Conjugation of enzymes or fluorescent dyes to antibodies or other targeting molecules for ELISA and other immunoassays.
• Biomaterial Engineering: Creating bioactive scaffolds for tissue engineering by linking cell-adhesive peptides to polymer matrices.
• Small Molecule Prodrug Development: Constructing cleavable linkages for targeted drug delivery systems.

Basic Information

Product Name	Mal-Peg4-Acid
CAS No.	518044-41-2
Molecular Formula	C19H31NO10
Molecular Weight	433.45 g/mol
Synonyms	Maleimide-PEG4-acid; 3-[2-[2-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]propanoic Acid; Mal-PEG4-CH2CH2COOH; 1-[2-[2-[2-[2-(2-Carboxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]-1H-pyrrole-2,5-dione; PEG4-(MAL)-Acid; Maleimide-PEG4-Propionic Acid; 4-Arm PEG Maleimide; (Acid-PEG4)-Maleimide
EINECS	Contact for details

Quality Control

Our Mal-Peg4-Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive bioconjugation applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Maleimide Functional Group Assay	≥ 90%
Acid Value (Titration)	Conforms to theoretical
Solubility	Soluble in DMSO, DMF, Acetonitrile, Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.