Description

Maleimido-Tri(Ethylene Glycol)-Propionic Acid is a heterobifunctional crosslinker featuring a maleimide group for thiol conjugation and a carboxylic acid group for amine coupling. This compound is essential for creating stable, site-specific bioconjugates, particularly in aqueous environments where its hydrophilic tri(ethylene glycol) spacer enhances solubility and reduces non-specific binding. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science who require precise and efficient protein or antibody modification.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to antibodies via cysteine residues.
• PEGylation Reagent: Functionalization of peptides, proteins, or nanoparticles with polyethylene glycol (PEG) chains to improve pharmacokinetics.
• Diagnostic Probe Conjugation: Labeling antibodies or proteins with fluorescent dyes, enzymes, or other detection moieties for immunoassays.
• Surface Functionalization: Immobilization of biomolecules onto chips, beads, or other solid supports for biosensor and microarray applications.
• Protein-Protein Crosslinking: Studying protein interactions or creating multi-specific protein complexes.

Basic Information

Product Name	Maleimido-Tri(Ethylene Glycol)-Propionic Acid
CAS No.	518044-40-1
Molecular Formula	C14H19NO8
Molecular Weight	329.30 g/mol
Synonyms	3-[2-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]propanoic Acid; Maleimide-PEG3-propionic acid; Mal-PEG3-COOH; 1-[8-(2-Carboxyethoxy)-3,6-dioxaoctyl]-1H-pyrrole-2,5-dione; Maleimido-PEG3-acid; mPEG3-Mal; TEG-Maleimide-Propionic Acid; N-(3-Carboxypropyl)maleimide triethylene glycol ester
EINECS	Contact for details

Quality Control

Our Maleimido-Tri(Ethylene Glycol)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for water content, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with lot-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.