Description

Glycocholic Acid Ethyl Ester is a high-purity conjugated bile acid derivative, serving as a critical intermediate and reference standard in advanced biochemical research and pharmaceutical development. Its primary value lies in its role as a precursor for synthesizing more complex bile acid analogs and as a tool for studying bile acid metabolism and receptor interactions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent sectors who require well-characterized biochemical building blocks.

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of novel therapeutic bile acid conjugates and prodrugs targeting metabolic and liver diseases.
• Biochemical Research: Used as a reference standard and substrate in studies of bile acid transporters (e.g., ASBT, NTCP), nuclear receptors (FXR, TGR5), and metabolic pathways.
• Diagnostic Reagent Development: Employed in the formulation of calibration standards and assay components for clinical diagnostic kits measuring bile acid profiles.
• Cell Culture & Membrane Studies: Utilized in research on membrane fluidity, micelle formation, and as a component in specialized cell culture media.
• Analytical Chemistry: Serves as a high-purity internal standard for quantitative analysis (e.g., LC-MS, HPLC) of bile acids in complex biological matrices.

Basic Information

Product Name	Glycocholic Acid Ethyl Ester
CAS No.	517904-33-5
Molecular Formula	C₂₈H₄₇NO₇
Molecular Weight	509.68 g/mol
Synonyms	Ethyl Glycocholate; N-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycine ethyl ester; Glycocholic acid ethyl ester; Ethyl 2-[(4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)acetate; Taurocholic Acid Ethyl Ester Analog
EINECS	Contact for details

Quality Control

Our Glycocholic Acid Ethyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.