Description

2,4,6-Tri-o-Butyryl-Myo-Inositol 1,3,5-Trisphosphate-Hexakis(Propionoxymethyl) Ester is a sophisticated, cell-permeable prodrug derivative of the critical second messenger, inositol 1,3,5-trisphosphate (Ins(1,3,5)P3). This compound is engineered to deliver Ins(1,3,5)P3 into intact cells, enabling researchers to study calcium signaling pathways with high precision and control. It is an essential tool for advanced biochemical and pharmacological research, particularly in neuroscience, cardiology, and cell biology. Global research institutions and pharmaceutical R&D departments rely on this high-purity chemical for investigating intracellular calcium dynamics and related physiological processes.

Application

• Intracellular Calcium Signaling Research: As a membrane-permeable precursor to Ins(1,3,5)P3, it is used to directly modulate intracellular calcium release from the endoplasmic reticulum in live cells.
• Neurobiology Studies: Critical for investigating the role of Ins(1,3,5)P3 receptors in neuronal function, synaptic plasticity, and neurodegenerative disease mechanisms.
• Cardiovascular Research: Employed to study calcium-induced calcium release (CICR) and its regulation in cardiac myocytes, relevant to arrhythmias and heart failure.
• Cell Physiology & Pharmacology: Used as a research tool to dissect G-protein coupled receptor (GPCR) pathways and the pharmacology of phosphoinositide signaling.
• Drug Discovery & Target Validation: Serves as a key reagent in high-throughput screening (HTS) assays and target validation for diseases involving dysregulated calcium homeostasis.
• Biochemical Mechanism Studies: Facilitates the study of enzyme kinetics, receptor binding, and downstream effector activation within intact cellular systems.

Basic Information

Product Name	2,4,6-Tri-o-Butyryl-Myo-Inositol 1,3,5-Trisphosphate-Hexakis(Propionoxymethyl) Ester
CAS No.	503158-15-4
Molecular Formula	C47H75O24P3
Molecular Weight	1117.0 g/mol (approx.)
Synonyms	Ins(1,3,5)P3/PM Hexapropionate; myo-Inositol 1,3,5-trisphosphate, 2,4,6-tri-O-butyryl-, hexakis(propionoxymethyl) ester; Hexakis(propionoxymethyl) 2,4,6-tri-O-butyryl-myo-inositol 1,3,5-trisphosphate; Ins(1,3,5)P3 hexakis(propionoxymethyl) ester, butyrylated; Cell-permeable Ins(1,3,5)P3 prodrug; IP3 prodrug, membrane permeable; D-myo-Inositol 1,3,5-trisphosphate, P1,P3,P5-(hexakis(propionoxymethyl)) ester, 2,4,6-tri-O-butyryl-
EINECS	Contact for details

Quality Control

This high-value biochemical is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Identity and purity are confirmed by advanced analytical techniques including NMR and HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each batch to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by weight)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.