Description

Aprepitant is a potent and highly selective neurokinin-1 (NK1) receptor antagonist, a critical active pharmaceutical ingredient (API) in the prevention of chemotherapy-induced nausea and vomiting (CINV). Its mechanism of action provides a significant advancement in supportive cancer care, offering superior efficacy when used in combination with other antiemetic agents. This compound is essential for pharmaceutical manufacturers developing injectable and oral formulations for oncology patients worldwide. Aprepitant CAS NO 502537-07-7 represents a high-value, specialized ingredient requiring stringent quality control from synthesis to final packaging.

Application

• Primary Pharmaceutical Ingredient: Core API in the manufacture of antiemetic drugs for the prevention of acute and delayed CINV.
• Combination Therapy Formulations: Used in fixed-dose combination products with 5-HT3 receptor antagonists and corticosteroids.
• Oral Dosage Forms: Key component in the production of capsules and tablets for post-chemotherapy nausea management.
• Injectable Formulations: Utilized in the development of intravenous (IV) infusion solutions for hospital and clinical use.
• Clinical Research & Development: Serves as a reference standard and building block in ongoing oncological and neurological research.
• Generic Drug Manufacturing: Critical for companies producing bioequivalent versions of established brand-name antiemetics.

Basic Information

Product Name	Aprepitant
CAS No.	502537-07-7
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1H-1,2,4-triazol-3-one; L-754030; MK-0869; Emend® (Brand Name); CJ-11,972; Neurokinin 1 Receptor Antagonist
EINECS	Contact for details

Quality Control

Our Aprepitant is manufactured under strict cGMP conditions, ensuring it meets or exceeds the stringent requirements of major pharmacopoeias, including USP and EP monographs. Every batch undergoes comprehensive analytical testing, including chiral purity verification, residual solvent analysis, and stringent control of related substances. A Certificate of Analysis (COA) documenting identity, assay, purity, and impurities is provided with each shipment to guarantee traceability and regulatory compliance for our global pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants and maintaining conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.10% Total impurities: NMT 0.5%
Chiral Purity (HPLC)	NMT 0.5% of any single enantiomer
Water Content (KF)	NMT 0.5%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.