Description

Diquafosol CAS NO 59985-21-6 is a synthetic dinucleotide derivative and a potent P2Y2 receptor agonist, representing a significant advancement in targeted therapeutic agents. Its primary value lies in its ability to stimulate the secretion of water and mucin from ocular surface cells, addressing the root cause of tear film instability. This makes it a critical raw material for the pharmaceutical industry, specifically for the formulation of ophthalmic solutions targeting dry eye disease and related ocular surface disorders.

Application

• Active Pharmaceutical Ingredient (API) in prescription ophthalmic solutions for the treatment of dry eye syndrome.
• Key intermediate in advanced pharmaceutical research focused on P2Y2 receptor-mediated pathways.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Component in preclinical and clinical studies for novel tear film stimulants.
• Material for formulating combination therapies aimed at severe ocular surface disease.

Basic Information

Product Name	Diquafosol
CAS No.	59985-21-6
Molecular Formula	C18H25N7O17P2
Molecular Weight	673.38 g/mol
Synonyms	Diquafosol Tetrasodium; INS365; UR-2922; 5'-O-[Hydroxy(phosphonooxy)phosphoryl]uridine 5'-(P'-→5')-guanosine Tetrasodium Salt; P1-(5'-Uridylyl) P4-(5'-guanosyl) Tetraphosphate Tetrasodium Salt; Diquafosol Sodium; Uridine 5'-(P1-(5'-uridylyl)-P4-(5'-guanosyl) tetraphosphate) tetrasodium salt
EINECS	Contact for details

Quality Control

Our Diquafosol is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and NMR. A Certificate of Analysis (COA) is provided with every shipment, detailing compliance with agreed specifications. We support development and commercial projects requiring adherence to cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 10 EU/mg
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.