Description

5-Methyldihydrofolic Acid is a key folate derivative and a vital intermediate in one-carbon metabolism. This compound is essential for research and development in advanced pharmaceutical synthesis and nutritional science. It is primarily utilized by manufacturers in the pharmaceutical, nutraceutical, and fine chemical industries for the production of high-purity active pharmaceutical ingredients (APIs) and specialized biochemical reagents.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of advanced chemotherapeutic agents and other specialty drugs targeting folate pathways.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, metabolic pathway analysis, and cellular biology research.
• Nutraceutical Development: Serves as a high-purity ingredient in the formulation of specialized dietary supplements and fortified foods.
• Reference Standard: Employed as a certified reference material (CRM) for quality control and analytical method development in QC laboratories.
• Diagnostic Reagents: Component in the manufacture of diagnostic kits and assays for clinical testing.

Basic Information

Product Name	5-Methyldihydrofolic Acid
CAS No.	59904-24-4
Molecular Formula	C20H25N7O6
Molecular Weight	459.46 g/mol
Synonyms	5-Methyl-5,6-dihydrofolic acid; 5-Methyl-DHF; 5-Methyl-7,8-dihydrofolic acid; 5-CH3-DHF; 5-Methyltetrahydrofolate precursor; (6S)-5-Methyl-5,6,7,8-tetrahydrofolic acid (related reduced form); L-5-Methyl-5,6-dihydrofolate
EINECS	Contact for details

Quality Control

Our 5-Methyldihydrofolic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical and research applications. Certificates of Analysis (COA) documenting all test results are available upon request, and we can support compliance with relevant pharmacopeial standards (e.g., USP) for qualified grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.