Description

Brimonidine is a highly selective α-2 adrenergic receptor agonist, recognized for its potent pharmacological activity. This compound is a critical active pharmaceutical ingredient (API) valued for its efficacy in managing intraocular pressure. It is primarily utilized by pharmaceutical manufacturers and research institutions in the ophthalmic and neurological sectors. Our supply ensures high purity and consistency, meeting the stringent demands of global regulatory frameworks.

Application

• Ophthalmic Solutions: Primary API in prescription eye drops for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.
• Neurological Research: Used as a research chemical in preclinical studies investigating α-2 adrenergic pathways, neuroprotection, and vascular regulation.
• Combination Therapies: Formulated alongside other agents like timolol or brinzolamide in advanced ophthalmic preparations for enhanced therapeutic effect.
• Pharmaceutical Development: Serves as a reference standard and key intermediate in the synthesis and quality control of finished dosage forms.
• Cosmeceutical Applications: Investigated for potential use in topical formulations targeting facial erythema and rosacea due to its vasoconstrictive properties.

Basic Information

Product Name	Brimonidine
CAS No.	59803-98-4
Molecular Formula	C11H10BrN5
Molecular Weight	292.13 g/mol
Synonyms	5-Bromo-6-(2-imidazolidinylideneamino)quinoxaline; UK-14,304-18; Brimonidine Tartrate (salt form); AGN 190342; Alphagan® (brand name); AGN-190342; Brimonidine base; UK 14304
EINECS	Contact for details

Quality Control

Our Brimonidine is manufactured under strict quality management systems. Each batch is tested to ensure compliance with high-purity pharmacopeial standards, including identification, assay, and impurity profile limits. A comprehensive Certificate of Analysis (COA) detailing results for appearance, purity (by HPLC), related substances, residual solvents, and heavy metals is provided with every shipment to guarantee traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.