Description

Heliotrine is a naturally occurring pyrrolizidine alkaloid (PA) with the CAS registry number 59532-50-2. This compound is of significant interest in research and development due to its specific biological activity and role as a chemical reference standard. It is primarily utilized by professionals in the pharmaceutical, toxicology, and analytical chemistry sectors who require high-purity, well-characterized compounds for method development, quality control, and investigative studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified analytical standard for the identification and quantification of pyrrolizidine alkaloids in drug substances, herbal materials, and finished products.
• Toxicological Research: Used in studies investigating the hepatotoxic and genotoxic mechanisms of pyrrolizidine alkaloids, crucial for safety assessments.
• Analytical Method Development: Employed as a key calibrant in developing and validating HPLC, LC-MS, and GC-MS methods for PA detection in complex matrices like food, feed, and botanicals.
• Quality Control & Assurance: Essential for in-house QC laboratories to ensure the absence or control of toxic PAs in raw materials and dietary supplements.
• Academic & Clinical Research: Supports fundamental research in natural product chemistry, phytochemistry, and the study of plant-derived toxins.

Basic Information

Product Name	Heliotrine
CAS No.	59532-50-2
Molecular Formula	C16H27NO5
Molecular Weight	313.39 g/mol
Synonyms	Heliotrine; (+)-Heliotrine; (3'R,7aR)-3'-Hydroxy-1,2,5,7a-tetrahydro-7H-pyrrolizin-7-ylmethyl 2-hydroxy-2-(1-methoxyethyl)-3-methylbutanoate; 7-(2-Hydroxy-2-isopropyl-3-methoxybutyryl)heliotridane; Heliotridane, 7-(2-hydroxy-2-isopropyl-3-methoxybutyryl)-
EINECS	Contact for details

Quality Control

Our Heliotrine is produced and handled under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity determination by HPLC, to ensure it meets the stringent requirements for a research-grade chemical. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.