Description

Alizapride is a potent and selective dopamine D2 and serotonin 5-HT3 receptor antagonist. This dual mechanism of action makes it a valuable pharmaceutical intermediate for the development of antiemetic and prokinetic medications. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the synthesis of drugs targeting chemotherapy-induced nausea, postoperative vomiting, and gastrointestinal motility disorders. Our supply ensures high purity and batch-to-batch consistency critical for regulatory compliance and formulation stability.

Application

• Key intermediate in the synthesis of antiemetic pharmaceutical formulations.
• Research and development of prokinetic agents for gastrointestinal disorders.
• Production of active pharmaceutical ingredients (APIs) for managing chemotherapy-induced nausea and vomiting (CINV).
• Manufacturing of drugs for the treatment of postoperative nausea and vomiting (PONV).
• Reference standard in analytical laboratories for quality control and method development.
• Biochemical research focusing on dopamine and serotonin receptor pathways.

Basic Information

Product Name	Alizapride
CAS No.	59338-93-1
Molecular Formula	C₁₆H₂₁ClN₄O₂
Molecular Weight	336.82 g/mol
Synonyms	Alizapride; Alizapridum; Alizapride Hydrochloride (common salt form); N-[(1-Allyl-2-pyrrolidinyl)methyl]-6-chloro-4-methoxy-1H-indazole-3-carboxamide; Litican; Plitican; Vergentan; BRL-24924; BRL 24924
EINECS	Contact for details

Quality Control

Our Alizapride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent purity and identity specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for active pharmaceutical ingredients (APIs) and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.