Description

Brimonidine is a highly selective α-2 adrenergic receptor agonist, a key active pharmaceutical ingredient (API) with significant therapeutic importance. Its primary value lies in its potent ability to lower intraocular pressure, making it a cornerstone in ophthalmic treatments. This compound is essential for pharmaceutical manufacturers and R&D facilities developing formulations for glaucoma and ocular hypertension. Brimonidine CAS NO 59308-98-4 represents a critical component in the production of safe and effective prescription eye care solutions.

Application

• Ophthalmic Solutions: Primary active ingredient in prescription eye drops for the treatment of open-angle glaucoma and ocular hypertension.
• Combination Therapies: Used in fixed-dose combination products with other intraocular pressure-lowering agents like timolol for enhanced therapeutic effect.
• Pharmaceutical R&D: Serves as a reference standard and key intermediate in the research and development of new neuroprotective and vasoconstrictive agents.
• API Manufacturing: Supplied as a high-purity bulk active pharmaceutical ingredient for formulation into final dosage forms by licensed drug manufacturers.
• Veterinary Ophthalmology: Investigated for use in treating glaucoma in companion animals.

Basic Information

Product Name	Brimonidine
CAS No.	59308-98-4
Molecular Formula	C11H10BrN5
Molecular Weight	292.13 g/mol
Synonyms	5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine; UK-14,304-18; Brimonidine tartrate (salt form); AGN 190342; Alphagan® (brand name); AGN 190342-LF; Brimonidine base; 2-[(4,5-Dihydro-1H-imidazol-2-yl)amino]-6-bromoquinoxaline
EINECS	Contact for details

Quality Control

Our Brimonidine is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing including identification, assay, and impurity profiling to ensure it meets stringent specifications. Certificates of Analysis (COA) are provided with every shipment, detailing compliance with relevant in-house standards and supporting its use as an API. We are committed to supply chain reliability and consistent quality for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.