Description

2-Hydroxy Desipramine-D6 Hcl is a deuterium-labeled internal standard critical for ensuring the accuracy and reliability of quantitative bioanalytical methods. This high-purity compound is essential for researchers and quality control laboratories requiring precise measurement of its parent drug and metabolites in complex biological matrices. It is primarily utilized in pharmaceutical research, forensic toxicology, and clinical diagnostics for method development and validation.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of desipramine and its metabolites in pharmacokinetic and bioequivalence studies.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetics (DMPK) research by enabling precise tracking of metabolic pathways.
• Forensic Analysis: Employed in toxicological screenings to confirm and quantify tricyclic antidepressant levels with high specificity.
• Clinical Diagnostics: Facilitates the development of robust assays for therapeutic drug monitoring (TDM) in patient samples.
• Method Validation: Serves as a reference material to validate analytical procedures according to ICH, FDA, and EMA guidelines.
• Metabolite Identification: Aids in the structural elucidation and confirmation of hydroxylated metabolites during drug development.

Basic Information

Product Name	2-Hydroxy Desipramine-D6 Hcl
CAS No.	59259-75-5
Molecular Formula	C18H16D6ClNO2
Molecular Weight	317.85 g/mol
Synonyms	2-Hydroxy Desipramine-D6 Hydrochloride; 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenzo[b,f]azepine-2-ol-D6 Hydrochloride; Desmethylimipramine-2-ol-D6 HCl; 2-OH-Desipramine-D6 HCl; Didesmethylimipramine-2-ol-D6 Hydrochloride; Deuterated 2-Hydroxy Desipramine HCl; 2-Hydroxydesipramine-d6 HCl
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy Desipramine-D6 Hcl is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment. Our quality assurance protocols are designed to meet the stringent requirements of analytical reference standard applications. A comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic purity, and related substances by HPLC and/or LC-MS is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.