Description

Trisialoganglioside Gt1B 3Na is a high-purity, complex glycosphingolipid featuring three sialic acid residues. This compound is a critical biochemical tool for neuroscience and immunology research, serving as a specific ligand and antigen. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for studying neuronal cell adhesion, signal transduction, and autoimmune disease mechanisms.

Application

• Neuroscience Research: Used as a high-affinity ligand to study neuronal cell surface interactions, synaptic plasticity, and neurodegenerative disease models.
• Immunology & Autoimmune Disease Studies: Acts as a target antigen in research for conditions like Guillain-Barré syndrome, where anti-ganglioside antibodies are implicated.
• Biomarker Development: Employed in the development of diagnostic assays and biosensors for detecting specific ganglioside expression.
• Membrane Biophysics: Serves as a key component in model membrane systems (e.g., lipid rafts) to investigate membrane structure and function.
• Reference Standard: Provides a certified standard for the quality control and quantification of gangliosides in pharmaceutical preparations and research materials.
• Drug Discovery & Vaccine Development: Utilized in screening platforms for therapeutic agents targeting ganglioside-mediated pathways and in conjugate vaccine research.

Basic Information

Product Name	Trisialoganglioside Gt1B 3Na
CAS No.	59247-13-1
Molecular Formula	C₁₀₈H₁₈₃N₅O₇₈ • 3Na
Molecular Weight	~2650 g/mol (monoisotopic)
Synonyms	Ganglioside Gt1b (sodium salt); Gt1b Ganglioside; II3(NeuAc)3-GgOse4Cer; Trisialotetraosylganglioside Gt1b; Neu5Acα2-3Galβ1-3GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glcβ1-1'Cer (sodium salt); Gt1B; Gt1b (3Na)
EINECS	Contact for details

Quality Control

Our Trisialoganglioside Gt1B 3Na is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and mass spectrometry for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and other critical parameters to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 5.0 %
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Functionally tested (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.