Description

Z-Arg-Pna Hcl CAS NO 59188-53-3 is a high-purity, chromogenic peptide substrate used as a critical reagent in enzymatic assays. This compound is essential for researchers and quality control laboratories requiring precise and reliable detection of specific protease activity. It is primarily utilized in the pharmaceutical, biotechnology, and diagnostic industries for biochemical research, drug discovery, and enzyme characterization.

Application

• Protease Activity Assays: As a specific chromogenic substrate for trypsin-like serine proteases, including thrombin, plasmin, and factor Xa.
• Biochemical Research: Used in kinetic studies and enzyme mechanism investigations to determine kinetic parameters (Km, Vmax).
• Pharmaceutical Development: Employed in high-throughput screening (HTS) platforms for identifying and characterizing potential protease inhibitors as drug candidates.
• Diagnostic Reagent Manufacturing: A key component in the formulation of diagnostic kits for clinical analysis of blood coagulation and fibrinolysis pathways.
• Quality Control (QC): Used in QC laboratories for the potency testing and standardization of therapeutic enzyme products.

Basic Information

Product Name	Z-Arg-Pna Hcl
CAS No.	59188-53-3
Molecular Formula	C20H25ClN6O4
Molecular Weight	448.91 g/mol
Synonyms	Benzyloxycarbonyl-Arginine-p-nitroanilide hydrochloride; Z-Arg-pNA HCl; Nα-CBZ-L-arginine 4-nitroanilide hydrochloride; Nα-Carbobenzoxy-L-arginine-p-nitroanilide hydrochloride; L-Arginine, N2-[(phenylmethoxy)carbonyl]-, 4-nitroanilide, hydrochloride; Chromogenic substrate S-2765 (related); Chromozym TH (related); CBZ-Arg-pNA HCl
EINECS	Contact for details

Quality Control

Our Z-Arg-Pna Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and diagnostic applications. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.