Description

Poly(Thioinosinic Acid) CAS NO 59126-38-4 is a synthetic polynucleotide analog derived from inosine, where the oxygen atom in the phosphate backbone is replaced by sulfur, forming a phosphorothioate linkage. This structural modification confers enhanced nuclease resistance and alters biological activity, making it a valuable tool for biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical developers exploring antiviral mechanisms, immunomodulation, and nucleic acid chemistry.

Application

• Biochemical Research: Used as a model compound to study the properties and interactions of phosphorothioate oligonucleotides.
• Antiviral Studies: Investigated for its potential to inhibit viral replication by interfering with viral polymerase activity.
• Immunology Research: Serves as an immune stimulant or adjuvant in studies of innate immune response activation via pattern recognition receptors.
• Nucleic Acid Chemistry: A key intermediate or reference standard in the synthesis and analysis of modified oligonucleotides.
• Enzyme Substrate/Inhibitor: Used to probe the specificity and mechanism of nucleases, polymerases, and other nucleic acid-metabolizing enzymes.
• Pharmaceutical Development: Employed in early-stage discovery for novel therapeutic agents targeting RNA viruses or for immunotherapeutic applications.

Basic Information

Item	Details
Product Name	Poly(Thioinosinic Acid)
CAS No.	59126-38-4
Molecular Formula	(C10H11N4O7PS)n
Molecular Weight	Contact for details
Synonyms	Poly(I) phosphorothioate; Polyinosinic acid phosphorothioate; Polythioinosinic acid; Poly(inosinic acid) thiophosphate; Poly I phosphorothioate; s-Poly I; PTI; Inosine polynucleotide phosphorothioate
EINECS	Contact for details

Quality Control

Our Poly(Thioinosinic Acid) is produced under controlled conditions to ensure batch-to-batch consistency for research applications. Quality is verified through a suite of analytical techniques including HPLC for purity assessment, UV-Vis spectroscopy for concentration and homogeneity, and gel electrophoresis for chain length distribution. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specifications is provided with each shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive). For long-term storage, desiccate under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (UV-Vis)	Characteristic absorption spectrum of inosine derivative
Purity (HPLC)	≥ 90% (Polymer peak)
Chain Length (n)	Contact for details (Typically specified as average size, e.g., 100-500 bases)
Solubility	Soluble in aqueous buffers (e.g., Tris-EDTA, PBS) and DMSO
Endotoxin Level	< 10 EU/mg (for cell culture applications)
Moisture Content (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.