Description

Mal-Pegn-Oh 2K, 5K, 10K, 20K is a series of maleimide-terminated poly(ethylene glycol) derivatives, a versatile heterobifunctional crosslinker with CAS number 58914-60-6. This compound is engineered for precise bioconjugation, enabling the stable attachment of thiol-containing biomolecules to other functionalized surfaces or molecules. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced material science, where controlled and site-specific coupling is required.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via engineered cysteine residues.
• PEGylation of Therapeutics: Modification of peptides, proteins, and enzymes to enhance solubility, stability, and circulation half-life.
• Surface Functionalization: Immobilization of proteins, antibodies, or other ligands onto biosensor chips, microarrays, and nanoparticles for diagnostic and research applications.
• Hydrogel Formation: Crosslinking agent in the synthesis of biocompatible hydrogels for drug delivery systems and tissue engineering scaffolds.
• Protein-Protein/Protein-Peptide Conjugation: Creating stable, defined complexes for structural studies, vaccine development, and synthetic biology.
• Liposome and Micelle Modification: Attaching targeting ligands or stealth PEG layers to lipid-based drug delivery vehicles.

Basic Information

Product Name	Mal-Pegn-Oh 2K, 5K, 10K, 20K
CAS No.	58914-60-6
Molecular Formula	C2n+4H4n+6NOn+3 (n varies with PEG chain length)
Molecular Weight	~2,000; ~5,000; ~10,000; ~20,000 g/mol
Synonyms	Maleimide-PEG-OH; MAL-PEG-OH; α-Maleimide-ω-hydroxy Poly(ethylene glycol); mPEG-Maleimide; PEG-MAL; Poly(ethylene glycol) maleimide; N-(2-Hydroxyethyl)maleimide PEG; 3-Maleimidopropionic acid-PEG-OH
EINECS	Contact for details

Quality Control

Our Mal-Pegn-Oh series is produced under a strict quality management system. Each batch is characterized to ensure consistent molecular weight, low polydispersity, and high functional group purity. Certificates of Analysis (COA) are provided, detailing specifications for assay, degree of substitution, and critical impurities. We support development under GMP-grade conditions for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Molecular Weight (SEC-MALS)	Nominal ± 10% (2K, 5K, 10K, 20K)
Polydispersity Index (PDI)	≤ 1.05
Maleimide Substitution	> 95%
Assay (HPLC)	> 98%
Water Content (KF)	< 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.