Description

(R)-(-)-γ-Toluenesulfonylmethyl-γ-Butyrolactone CAS NO 58879-33-7 is a high-value, chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its core value lies in its utility for constructing complex, enantiomerically pure molecules, which are critical for developing active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce chirality into target molecules.
• Natural Product Synthesis: Employed in the complex total synthesis of natural products where the γ-butyrolactone moiety is a structural component.
• Agrochemical Research: Serves as a building block for developing chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science: Potential monomer or precursor for synthesizing specialized polymers with unique optical or mechanical properties.
• Academic & Process R&D: Utilized in research laboratories for method development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	(R)-(-)-γ-Toluenesulfonylmethyl-γ-Butyrolactone
CAS No.	58879-33-7
Molecular Formula	C13H16O4S
Molecular Weight	268.33 g/mol
Synonyms	(R)-(-)-γ-Toluenesulfonylmethyl-γ-Butyrolactone; (R)-4-[(Tosyl)methyl]dihydrofuran-2(3H)-one; (R)-(-)-4-(p-Tolylsulfonylmethyl)-γ-butyrolactone; (R)-(-)-4-(Tosylmethyl)butyrolactone; (R)-(-)-Tosylmethylbutyrolactone; (R)-TMBL; (R)-(-)-γ-(p-Toluenesulfonylmethyl)-γ-butyrolactone; (3R)-4-[(4-Methylphenyl)sulfonylmethyl]oxolan-2-one
EINECS	Contact for details

Quality Control

Our (R)-(-)-γ-Toluenesulfonylmethyl-γ-Butyrolactone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.