Description

Chromozym Pk is a synthetic chromogenic substrate specifically designed for the selective and sensitive determination of prekallikrein (Fletcher factor) and kallikrein activity. This compound is a critical diagnostic reagent in clinical chemistry and hemostasis research, enabling precise measurement of enzymatic activity in plasma and other biological fluids. It is essential for laboratories and manufacturers in the in-vitro diagnostics (IVD), pharmaceutical research, and clinical research sectors, providing a reliable tool for studying the contact activation pathway of blood coagulation.

Application

• Clinical Diagnostics: Primary substrate in automated and manual assays for the quantitative determination of prekallikrein and kallikrein in human plasma.
• Hemostasis Research: Used in research laboratories to investigate the kinin-kallikrein system, contact activation, and related inflammatory pathways.
• IVD Kit Manufacturing: A key raw material for producing reagent kits and calibrators used in coagulation analyzers.
• Pharmaceutical Development: Employed in drug discovery and development for screening and evaluating potential inhibitors of kallikrein for therapeutic applications.
• Quality Control: Used by plasma fractionation facilities and biopharmaceutical companies to monitor process-related enzyme activities.

Basic Information

Product Name	Chromozym Pk
CAS No.	58840-30-5
Molecular Formula	C20H27N7O5
Molecular Weight	445.48 g/mol
Synonyms	H-D-Prolyl-L-phenylalanyl-L-arginine 4-nitroanilide dihydrochloride; Prekallikrein Activator Substrate; S-2302 (historical); Kallikrein Substrate Chromozym PK; D-Phe-Pip-Arg-pNA · 2HCl; Benzoyl-Phe-Val-Arg-p-nitroanilide hydrochloride (related); Chromogenic substrate for prekallikrein
EINECS	Contact for details

Quality Control

Every batch of Chromozym Pk is manufactured and tested to meet stringent quality standards suitable for diagnostic and research use. Our quality assurance includes rigorous identity confirmation, purity assessment, and functional activity testing. A comprehensive Certificate of Analysis (COA) detailing purity, assay, water content, and specific performance in a kallikrein assay is provided with each shipment to ensure traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a desiccated environment to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solubility	Clear, colorless solution in water
Functional Activity	Conforms to reference standard in kallikrein assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.