Description

(3A,5B,7A)-23-Carboxy-7-Hydroxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid CAS NO 58814-71-4 is a high-purity, bile acid-derived glucuronide conjugate, representing a critical intermediate and reference standard in advanced pharmaceutical research and development. Its precise stereochemistry and functional groups make it an essential tool for studying metabolic pathways, drug detoxification, and bile acid biochemistry. This compound is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the synthesis of novel therapeutics, metabolite identification, and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantitative and qualitative analysis (HPLC, LC-MS) of drug metabolites and endogenous compounds.
• Metabolite Synthesis & Identification: Serves as a key synthetic intermediate or a model compound for identifying and characterizing Phase II glucuronidation metabolites of steroidal drugs and bile acids.
• Biochemical Research: Employed in studies investigating the enterohepatic circulation, transporter interactions, and the biological activity of conjugated bile acids.
• Enzyme Activity Assays: Utilized as a specific substrate for studying the kinetics and inhibition of UDP-glucuronosyltransferase (UGT) enzymes.
• Diagnostic Reagent Development: Acts as a critical component in developing high-sensitivity diagnostic kits and calibrators for liver function and metabolic disorders.

Basic Information

Item	Detail
Product Name	(3A,5B,7A)-23-Carboxy-7-Hydroxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid
CAS No.	58814-71-4
Molecular Formula	C31H48O10
Molecular Weight	580.71 g/mol
Synonyms	7-Hydroxy-3,24-dinor-5β-cholan-23-oic acid 3-yl β-D-glucopyranosiduronic acid; Tauro-7α-hydroxy-3-oxochol-4-en-24-oic acid glucuronide (related derivative); Norcholanic acid glucuronide; Bile acid glucuronide conjugate; 3α,5β,7α-Trihydroxy-24-nor-23-cholanoyl-β-D-glucuronide; 58814-71-4; Glucuronide of (3α,5β,7α)-23-carboxy-7-hydroxy-24-norcholan-3-ol
EINECS	Contact for details

Quality Control

Every batch of (3A,5B,7A)-23-Carboxy-7-Hydroxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) including results from HPLC, NMR, and MS is supplied with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.