Description

Dextran, 14C-Methylated is a radiolabeled, chemically modified polysaccharide derivative of dextran, where specific hydroxyl groups have been methylated and the methyl group is tagged with the Carbon-14 (14C) radioisotope. This compound is critically important for tracer studies, metabolic pathway analysis, and pharmacokinetic research, providing a powerful tool for tracking molecular behavior in complex biological and chemical systems. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced biomaterial and drug delivery system development.

Application

• Tracer and Metabolic Studies: Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of dextran-based compounds and related polymers in biological systems.
• Drug Delivery Research: Employed in the development and evaluation of novel drug delivery vehicles, such as nanoparticles and hydrogels, to track carrier fate and drug release profiles.
• Biomaterial Science: Facilitates research on biocompatibility, biodegradation rates, and in vivo performance of dextran-based medical devices and implants.
• Membrane and Permeability Assays: Acts as a standard or probe in studies investigating vascular permeability, blood-brain barrier function, and glomerular filtration.
• Chromatography and Standardization: Serves as a calibrated molecular size standard in gel permeation chromatography (GPC) or size exclusion chromatography (SEC) for analytical method development.
• Enzyme Substrate Studies: Used in biochemical research to investigate the activity and specificity of dextranases and other carbohydrate-modifying enzymes.

Basic Information

Product Name	Dextran, 14C-Methylated
CAS No.	58798-70-2
Molecular Formula	(C6H10O5)n (with 14C-labeled methyl groups)
Molecular Weight	Variable (Depends on dextran chain length and degree of methylation)
Synonyms	14C-Methyl Dextran; Carbon-14 Labeled Methylated Dextran; Radiolabeled Methyl Dextran; [14C]Methyl-Dextran; Methylated Dextran-14C; Dextran Methyl Ether-14C; (1→6)-α-D-Glucan, methylated, 14C-labeled
EINECS	Contact for details

Quality Control

Every batch of Dextran, 14C-Methylated is produced and controlled under a strict quality management system. Product specifications, including radiochemical purity, specific activity, degree of substitution, and molecular weight distribution, are verified using advanced analytical techniques such as HPLC with radiometric detection and SEC-MALS. A comprehensive Certificate of Analysis (COA), detailing all test results, is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term stability, consider storage under desiccant or inert atmosphere. Handle and dispose of in accordance with all applicable local, national, and international regulations for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Specific Activity	Customizable (e.g., 10-100 mCi/mmol)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 90%
Degree of Substitution (NMR/Titration)	As per customer requirement
Molecular Weight (SEC)	Specified range (e.g., 10 kDa, 40 kDa, 70 kDa)
Solubility	Soluble in water, DMSO
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.