Description

(S)-Propranolol-o-β-D-Glucuronide Min. 95% is a high-purity, stereochemically defined metabolite of the β-blocker propranolol, conjugated with glucuronic acid. This compound is essential for pharmaceutical research and development, serving as a critical reference standard for analytical method validation and metabolic studies. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK), bioanalytical chemistry, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification of propranolol metabolites in biological matrices via LC-MS/MS or HPLC.
• Drug Metabolism & Pharmacokinetics (DMPK): Critical for studying the Phase II glucuronidation pathway of (S)-propranolol, aiding in understanding drug clearance and bioavailability.
• Bioanalytical Method Development: Serves as a key calibrant and quality control sample in developing and validating robust analytical methods for clinical and pre-clinical studies.
• Impurity Identification and Profiling: Used to identify and quantify process-related or degradation impurities in propranolol API and finished dosage forms.
• Enzymology Studies: Employed as a substrate to investigate the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes.
• Toxicology and Safety Assessment: Supports metabolite safety testing (MIST) assessments by providing a pure standard for metabolite characterization.

Basic Information

Product Name	(S)-Propranolol-o-β-D-Glucuronide Min. 95%
CAS No.	58657-78-6
Molecular Formula	C22H33NO8
Molecular Weight	439.50 g/mol
Synonyms	(S)-Propranolol O-β-D-Glucuronide; 1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol β-D-Glucopyranosiduronic Acid; Propranolol Glucuronide (S-isomer); (S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol β-D-Glucuronide; (S)-Propranolol Glucuronide; (S)-Propranolol β-D-Glucuronide; 4-{[(2S)-1-[(1-Methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxane-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (S)-Propranolol-o-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	Min. 95.0%
Chiral Purity (HPLC)	Min. 98.0% (S-isomer)
Water Content (KF)	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.