Description

Aminopterin is a potent folic acid antagonist and classical antifolate compound. It serves as a critical biochemical tool for studying cell metabolism and proliferation, particularly in research involving dihydrofolate reductase (DHFR) inhibition. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and life science sectors, supporting applications from fundamental biochemical research to targeted therapeutic development.

Application

• Biochemical Research: Used as a selective inhibitor of dihydrofolate reductase (DHFR) in enzymatic and cellular studies.
• Cell Culture & Selection: Employed in media for the selection of transfected cells in genetic engineering and biotechnology workflows.
• Cancer Research: Investigated as a reference compound in studies of antifolate mechanisms and chemotherapeutic resistance.
• Pharmacology & Toxicology: Serves as a model compound for studying folate metabolism and its role in cellular processes.
• Reference Standard: Used as a high-purity analytical standard in pharmaceutical quality control and method development.
• Academic Research: A key reagent in university and institutional labs for teaching and research in biochemistry and molecular biology.

Basic Information

Product Name	Aminopterin
CAS No.	58602-66-7
Molecular Formula	C19H20N8O5
Molecular Weight	440.41 g/mol
Synonyms	4-Aminofolic Acid; 4-Aminopteroylglutamic Acid; NSC-739; 4-Amino-PGA; L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-; Aminopterine; 2,4-Diamino-4-deoxypteroylglutamate; 4-Amino-4-deoxyfolic acid
EINECS	Contact for details

Quality Control

Our Aminopterin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is supplied with a detailed Certificate of Analysis (COA). We support research and development with material suitable for use as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.