Description

Meprobamate n-β-D-Glucuronide is a major, pharmacologically inactive metabolite of the anxiolytic drug meprobamate, formed via glucuronidation in the liver. This reference standard is critical for analytical and research applications, providing a definitive benchmark for accurate quantification and metabolic profiling. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units for drug metabolism studies, bioanalytical method development, and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative analysis of meprobamate and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance rates, and excretion profiles of meprobamate.
• Bioanalytical Method Development & Validation: Essential for developing and validating precise HPLC, LC-MS/MS, or GC-MS methods for therapeutic drug monitoring (TDM) or forensic analysis.
• Forensic Toxicology: Employed as a calibrant or control in the confirmation and quantification of meprobamate exposure in clinical and post-mortem toxicology.
• Impurity Profiling: Used to identify and quantify related substances or degradation products in meprobamate active pharmaceutical ingredient (API) batches.
• Clinical Research: Supports studies on patient adherence, pharmacokinetic variability, and drug-drug interactions involving meprobamate.

Basic Information

Product Name	Meprobamate n-β-D-Glucuronide
CAS No.	58569-76-9
Molecular Formula	C15H24N2O9
Molecular Weight	376.36 g/mol
Synonyms	Meprobamate Glucuronide; Meprobamate β-D-Glucuronide; 2-[(3-Methylbutyl)carbamoyl]amino]-2-methylpropyl β-D-Glucopyranosiduronic Acid; Meprobamate N-Glucuronide; Meprobamate 1-β-Glucuronide; Meprobamate N-β-D-Glucopyranosiduronic Acid; Meprobamate Metabolite Glucuronide
EINECS	Contact for details

Quality Control

Our Meprobamate n-β-D-Glucuronide is manufactured under strict quality management systems. Each batch is subjected to rigorous identity confirmation, purity assay, and impurity profiling using advanced analytical techniques including HPLC, LC-MS, and NMR to ensure compliance with research and reference standard requirements. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.