Description

Polyethylene Glycol Monomethyl Ether Tosylate is a versatile chemical intermediate, primarily valued for its role as an effective alkylating agent and a key building block in organic synthesis. Its importance lies in its ability to introduce polyether chains with terminal functional groups, enabling the creation of tailored polymers and specialty chemicals. This product is essential for researchers and manufacturers in the pharmaceutical, polymer, and material science industries seeking to develop advanced formulations and functional materials.

Application

• Pharmaceutical Intermediate: Used in the synthesis of prodrugs, polymer-drug conjugates, and other active pharmaceutical ingredients (APIs) requiring PEGylation for enhanced solubility and bioavailability.
• Polymer Chemistry: Serves as a crucial monomer or initiator for the preparation of functional polyethers, block copolymers, and non-ionic surfactants with controlled architectures.
• Surface Modification Agent: Employed to graft hydrophilic polyethylene glycol (PEG) chains onto surfaces, particles, or biomaterials to improve biocompatibility and reduce non-specific binding.
• Crosslinking Agent: Facilitates the formation of polymer networks and hydrogels in material science and biomedical engineering applications.
• Chemical Research: A valuable reagent in organic synthesis laboratories for nucleophilic substitution reactions and the introduction of tosylate leaving groups attached to PEG spacers.
• Specialty Additives: Used in the formulation of advanced lubricants, dispersants, and processing aids where specific chain length and end-group functionality are required.

Basic Information

Product Name	Polyethylene Glycol Monomethyl Ether Tosylate
CAS No.	58320-73-3
Molecular Formula	CnH2n+2O(n+1)S (Variable based on PEG chain length 'n')
Molecular Weight	Variable (Contact for details on specific chain length)
Synonyms	mPEG-OTs; Poly(ethylene glycol) methyl ether tosylate; PEG monomethyl ether tosylate; Methoxy PEG tosylate; α-Methyl-ω-tosyl-poly(ethylene glycol); Polyoxyethylene monomethyl ether tosylate; Tosyl-PEG-OMe; PEG Methyl Ether p-Toluenesulfonate
EINECS	Contact for details

Quality Control

Our Polyethylene Glycol Monomethyl Ether Tosylate is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure consistency, purity, and compliance with customer specifications. Certificates of Analysis (COA) detailing key parameters such as assay, degree of tosylation, polydispersity, and residual solvent levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to prevent absorption of atmospheric moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (Titration/NMR)	≥ 95%
Degree of Tosylation	≥ 90%
Average Molecular Weight (Mn)	As per customer grade (e.g., 350, 550, 750, 2000, 5000 Da)
Polydispersity Index (PDI)	≤ 1.05 - 1.20 (Grade dependent)
Water Content (KF)	≤ 0.5%
Residual Solvent (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.