Description

Citric Acid, [1,5-14C] is a carbon-14 labeled isotopologue of citric acid, specifically radiolabeled at the 1 and 5 carbon positions. This compound is essential for conducting precise metabolic and biochemical tracer studies, enabling researchers to track the fate of citric acid in complex biological and chemical systems. It is a critical tool for scientists in pharmaceutical development, agricultural chemistry, and environmental research who require high-specific-activity tracers to elucidate metabolic pathways and degradation mechanisms.

Application

• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to map the citric acid cycle (Krebs cycle) and related biochemical pathways.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand how pharmaceutical compounds are processed.
• Environmental Fate Studies: Tracks the biodegradation and environmental breakdown of citric acid and related compounds in soil and water systems.
• Agricultural Research: Investigates plant nutrient uptake, metabolism, and the role of organic acids in soil chemistry.
• Biochemical Assay Development: Serves as a labeled substrate or standard in enzymatic assays and diagnostic test development.
• Synthesis of Labeled Compounds: Acts as a labeled building block for the synthesis of more complex carbon-14 labeled molecules for research.

Basic Information

Product Name	Citric Acid, [1,5-14C]
CAS No.	58308-53-5
Molecular Formula	C6H8O7 (with 14C at positions 1 & 5)
Molecular Weight	~194.12 g/mol (exact mass depends on specific activity)
Synonyms	1,5-14C-Citric Acid; [1,5-14C]Citric Acid; 2-Hydroxy-1,2,3-propanetricarboxylic-1,5-14C Acid; (1,5-14C)Citric Acid; Carbon-14 Labeled Citric Acid; Tracer Citric Acid; Radiolabeled Citric Acid; Krebs Cycle Tracer
EINECS	Contact for details

Quality Control

Every batch of our Citric Acid, [1,5-14C] is manufactured and analyzed under strict quality systems to ensure high chemical and radiochemical purity. Product identity and purity are verified by advanced analytical techniques including HPLC and radio-HPLC. Certificates of Analysis (COA) are provided with each shipment, detailing specific activity, radiochemical purity, chemical purity, and solvent composition. Our quality commitment supports research requiring reliable and consistent tracer materials for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended cold temperatures (typically -20°C or as specified on the label) to maintain stability and specific activity. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or solution
Identification (IR/HPLC)	Conforms to reference standard
Specific Activity	Customizable (mCi/mmol range)
Radiochemical Purity (Radiometric HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent (if supplied as solution)	Water or specified aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.