Description

n-(Trifluoroacetyl)-L-Isoleucine 1-Methylbutyl Ester is a specialized chiral building block and protected amino acid derivative. This compound is critical for the synthesis of complex peptides and peptidomimetics, offering a protected isoleucine side chain with enhanced lipophilicity for improved membrane permeability. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced medicinal chemistry, proteomics research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Proteomics Research: Used in the study of protein structure and function, including the synthesis of custom peptide sequences for biochemical assays.
• Medicinal Chemistry: Serves as a building block for creating libraries of novel compounds in drug discovery programs.
• Bioconjugation: Can be employed in the preparation of peptide conjugates for diagnostic or targeted delivery applications.
• Asymmetric Synthesis: Utilized in stereoselective synthesis due to its fixed L-configuration, ensuring the chirality of the final product.
• Academic Research: A valuable reagent for university and institutional labs studying peptide chemistry and amino acid derivatives.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Isoleucine 1-Methylbutyl Ester
CAS No.	57983-41-2
Molecular Formula	C13H22F3NO3
Molecular Weight	297.32 g/mol
Synonyms	L-Isoleucine, N-[(trifluoroacetyl)-, 1-methylbutyl ester; 1-Methylbutyl N-(trifluoroacetyl)-L-isoleucinate; N-(Trifluoroacetyl)-L-isoleucine 1-methylbutyl ester; N-TFA-L-Isoleucine 1-methylbutyl ester; (2S,3S)-2-[(Trifluoroacetyl)amino]-3-methylpentanoic acid 1-methylbutyl ester; (2S,3S)-3-Methyl-2-(2,2,2-trifluoroacetamido)pentanoic acid 2-pentyl ester
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Isoleucine 1-Methylbutyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and specific test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.