Description

o-Desmethylpyrilamine is a key pharmaceutical intermediate and metabolite of the antihistamine pyrilamine. This compound is of significant value in the research and development of active pharmaceutical ingredients (APIs) and for use as a certified reference standard in analytical laboratories. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical service providers for synthesis, quality control, and metabolic studies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced antihistamine APIs and related compounds.
• Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control testing in pharmaceutical laboratories.
• Metabolite Studies: Essential for pharmacokinetic and drug metabolism research to understand the biotransformation pathways of pyrilamine.
• Impurity Standard: Employed to identify, quantify, and control process-related impurities and degradation products in pharmaceutical formulations.
• Research Chemical: Utilized in academic and industrial research for pharmacological studies and the development of new therapeutic agents.

Basic Information

Product Name	o-Desmethylpyrilamine
CAS No.	57830-29-2
Molecular Formula	C16H21N3O
Molecular Weight	271.36 g/mol
Synonyms	2-[(2-Dimethylaminoethyl)(p-methoxybenzyl)amino]pyridine; N-Desmethylpyrilamine; Pyrilamine Impurity B; Pyrilamine Metabolite; 2-[[2-(Dimethylamino)ethyl](4-methoxyphenyl)methyl]amino]pyridine; N-Desmethylpyrilamine Maleate; N-Desmethyl Mepyramine
EINECS	Contact for details

Quality Control

Our o-Desmethylpyrilamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical intermediate and reference standard applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.