Description

Boc-D-Nva-Oh is a high-purity, protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc) derivative of D-Norvaline. This compound serves as a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and molecular structure. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, medicinal chemistry, and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential incorporation of the D-norvaline residue into peptide chains, enabling the creation of peptides with enhanced metabolic stability and specific biological activity.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of peptide-based pharmaceuticals, enzyme inhibitors, and receptor agonists/antagonists where the unique properties of D-amino acids are required.
• Bioconjugation & Labeling: Acts as a precursor for creating custom peptide tags or linkers used in antibody-drug conjugates (ADCs), diagnostic probes, and other bioconjugation strategies.
• Chemical Biology Research: Employed in the synthesis of peptide libraries for high-throughput screening and structure-activity relationship (SAR) studies to understand protein-protein interactions.
• Production of Custom Peptides: Essential for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients in academia and industry.

Basic Information

Item	Detail
Product Name	Boc-D-Nva-Oh
CAS No.	57521-85-4
Molecular Formula	C10H19NO4
Molecular Weight	217.26 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)pentanoic acid; D-Norvaline, N-[(1,1-dimethylethoxy)carbonyl]-; Boc-D-2-Aminopentanoic acid; Boc-D-Norvaline; N-Boc-D-norvaline; N-tert-Butoxycarbonyl-D-norvaline; (R)-2-(tert-Butoxycarbonylamino)pentanoic acid; BOC-D-NVA-OH
EINECS	Contact for details

Quality Control

Our Boc-D-Nva-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and chiral analysis to confirm enantiomeric excess. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Melting Point	Contact for details
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.