Description

(-)-1 4-Di-o-Tosyl-L-Threitol is a high-purity chiral building block and protecting group reagent of significant importance in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with precise stereochemistry, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for asymmetric synthesis and process development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially nucleoside analogs and antiviral drugs.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce enantioselectivity.
• Protecting Group Chemistry: The tosyl groups serve as effective protecting groups for diols in multi-step synthetic sequences.
• Agrochemical Research: Employed in the development of chiral pesticides and herbicides where specific stereochemistry impacts biological activity.
• Academic & R&D: A valuable tool for methodological development in organic chemistry laboratories and for synthesizing reference standards.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, flavors, and fragrances requiring defined stereocenters.

Basic Information

Product Name	(-)-1 4-Di-o-Tosyl-L-Threitol
CAS No.	57495-46-2
Molecular Formula	C20H26O6S2
Molecular Weight	426.55 g/mol
Synonyms	L-Threitol, 1,4-di-O-tosylate; (2S,3S)-1,4-Bis[(4-methylphenyl)sulfonyloxy]butane-2,3-diol; 1,4-Di-O-tosyl-L-threitol; Ditosyl-L-threitol; (-)-1,4-Ditosyl-L-threitol; (2S,3S)-1,4-Bis(tosyloxy)butane-2,3-diol; L-Threitol 1,4-ditosylate
EINECS	Contact for details

Quality Control

Our (-)-1 4-Di-o-Tosyl-L-Threitol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.