Description

Benzyloxycarbonyl- (Glycyl-Prolyl-Proline)8- Methyl Ester is a synthetic, protected oligopeptide sequence designed for advanced research and development. This compound is a critical building block in peptide chemistry, offering a precisely defined structure for constructing complex biomolecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for applications in drug discovery, proteomics, and as a standard for analytical method development.

Application

• Peptide Synthesis Intermediate: Serves as a key protected fragment for the solid-phase or solution-phase synthesis of longer, biologically active peptides.
• Pharmaceutical Research: Used in the discovery and development of novel therapeutic agents targeting collagenase and related enzymes, given its (Proline-Glycine-Proline) repeating motif.
• Biochemical Standard: Acts as a high-purity reference standard for calibrating analytical instruments like HPLC and Mass Spectrometry in quality control laboratories.
• Enzyme Substrate Studies: Employed in vitro to study the kinetics and inhibition profiles of collagen-degrading enzymes such as matrix metalloproteinases (MMPs).
• Academic Research: Utilized in university and institutional labs for fundamental studies on peptide structure, stability, and folding dynamics.
• Bioconjugation: The reactive ester and protecting groups enable its use in creating peptide-polymer or peptide-antibody conjugates for targeted drug delivery systems.

Basic Information

Product Name	Benzyloxycarbonyl- (Glycyl-Prolyl-Proline)8- Methyl Ester
CAS No.	57463-43-1
Molecular Formula	C96H128N24O28
Molecular Weight	2065.2 g/mol
Synonyms	Z-(Gly-Pro-Pro)8-OMe; Cbz-(Gly-Pro-Pro)8-OMe; Benzyloxycarbonyl-Glycyl-Prolyl-Proline Octamer Methyl Ester; Z-Gly-Pro-Pro-Gly-Pro-Pro-Gly-Pro-Pro-Gly-Pro-Pro-Gly-Pro-Pro-Gly-Pro-Pro-Gly-Pro-Pro-Gly-Pro-Pro-OMe; (Pro-Pro-Gly)8 Methyl Ester, Nα-Benzyloxycarbonyl-; Collagen-like Peptide Fragment; Protected (Gly-Pro-Pro)8 Sequence
EINECS	Contact for details

Quality Control

Every batch of our Benzyloxycarbonyl- (Glycyl-Prolyl-Proline)8- Methyl Ester is manufactured and tested under strict quality management systems. We ensure high purity and batch-to-batch consistency through comprehensive analytical protocols including HPLC, MS, and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformity to customer specifications. Our quality commitment supports applications requiring GMP-grade materials for preclinical and research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular ion peak [M+H]+ confirmed
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 90.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.