Description

Octaethylene Glycol Di(p-Toluenesulfonate) is a high-purity, bifunctional chemical intermediate featuring a long polyethylene glycol (PEG) spacer terminated with reactive tosylate groups. This compound is critical for the controlled synthesis of complex molecules, enabling the precise introduction of hydrophilic PEG linkers or the creation of sophisticated macrocyclic structures. It is primarily sought by research and development teams in the pharmaceutical, biotechnology, and advanced materials sectors for applications in drug delivery systems, bioconjugation, and polymer chemistry.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing prodrugs, antibody-drug conjugates (ADCs), and targeted therapeutic agents.
• PEGylation Reagent: Used to introduce long, flexible polyethylene glycol chains to peptides, proteins, or small molecules to enhance solubility, stability, and circulation time.
• Crosslinking Agent: Employed in polymer chemistry and hydrogel formation due to its bifunctional reactivity.
• Macrocycle Synthesis: Serves as a precursor in the construction of crown ether analogs and other macrocyclic compounds for sensing or catalysis.
• Surface Modification: Used to functionalize nanoparticles or solid supports with PEG layers to improve biocompatibility and reduce non-specific binding.
• Chemical Biology Tool: A versatile linker for creating chemical probes and bioconjugates for diagnostic and research applications.

Basic Information

Product Name	Octaethylene Glycol Di(p-Toluenesulfonate)
CAS No.	57436-38-1
Molecular Formula	C30H46O13S2
Molecular Weight	678.80 g/mol
Synonyms	PEG8 ditosylate; Octaethylene glycol ditosylate; Diethylene glycol octamer ditosylate; 3,6,9,12,15,18,21,24-Octaoxahexacosane-1,26-diyl bis(4-methylbenzenesulfonate); 1,26-Bis(tosyloxy)-3,6,9,12,15,18,21,24-octaoxahexacosane; p-Toluenesulfonic acid octaethylene glycol diester; Tetraethylene glycol ditosylate dimer
EINECS	Contact for details

Quality Control

Our Octaethylene Glycol Di(p-Toluenesulfonate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.