Description

17,21-Bis(Trimethylsiloxy)-5β-Pregnane-3,20-Dione Bis(o-Methyl Oxime) is a high-purity, advanced steroid derivative featuring protective trimethylsilyl (TMS) ether and oxime functional groups. This compound serves as a critical protected intermediate in the multi-step synthesis of complex steroid-based pharmaceuticals and fine chemicals. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents and high-value specialty molecules.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of steroid-based active pharmaceutical ingredients (APIs).
• Organic Synthesis Building Block: Used in complex organic transformations where protected ketone and hydroxyl functionalities are required.
• Steroid Chemistry Research: Enables the study of structure-activity relationships (SAR) and the development of new steroid analogs in academic and industrial research settings.
• Fine Chemical Manufacturing: Employed in the synthesis of high-purity, specialty chemicals for advanced material science and biotechnology applications.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	17,21-Bis(Trimethylsiloxy)-5β-Pregnane-3,20-Dione Bis(o-Methyl Oxime)
CAS No.	57305-38-1
Molecular Formula	C30H56N2O4Si2
Molecular Weight	564.95 g/mol
Synonyms	5β-Pregnane-3,20-dione, 17,21-bis[(trimethylsilyl)oxy]-, bis(O-methyloxime); 17,21-Bis-O-(trimethylsilyl)-5β-pregnane-3,20-dione dioxime methyl ether; 3,20-Bis(methyloximino)-5β-pregnane-17α,21-diol 17,21-bis(trimethylsilyl) ether; Pregnane-3,20-dione bis(O-methyloxime) 17,21-bis(trimethylsilyl) ether; Steroid TMS ether oxime derivative
EINECS	Contact for details

Quality Control

Our 17,21-Bis(Trimethylsiloxy)-5β-Pregnane-3,20-Dione Bis(o-Methyl Oxime) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.