Description

Pregn-4-Ene-3,20-Dione, 11,17-Bis[(Trimethylsilyl)Oxy]-, Bis(o-Methylo Xime), (11Beta)- is a high-purity, protected steroid derivative designed for advanced pharmaceutical research and synthesis. This compound is a critical synthetic intermediate, valued for its role in the development of novel steroid-based therapeutics and analytical reference standards. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid hormones and their analogs.
• Reference Standard: Used as a high-purity analytical standard in method development and quality control for steroid analysis.
• Process Chemistry: Employed in route scouting and optimization for the production of active pharmaceutical ingredients (APIs).
• Biochemical Research: Serves as a precursor or probe in studying steroid receptor interactions and metabolic pathways.
• Custom Synthesis: A starting material for the preparation of specialized, labeled (e.g., deuterated) steroid compounds.
• Academic Research: Utilized in university and institutional labs for exploratory chemistry and drug discovery projects.

Basic Information

Item	Detail
Product Name	Pregn-4-Ene-3,20-Dione, 11,17-Bis[(Trimethylsilyl)Oxy]-, Bis(o-Methylo Xime), (11Beta)-
CAS No.	57305-37-0
Molecular Formula	C30H52N2O4Si2
Molecular Weight	560.92 g/mol
Synonyms	11β,17β-Bis(trimethylsilyloxy)pregn-4-ene-3,20-dione bis(O-methyloxime); 11β,17β-Bis-O-(trimethylsilyl)cortisone bis(O-methyloxime); Cortisone 11β,17β-bis(trimethylsilyl ether) bis(O-methyloxime); 57305-37-0; (11β)-11,17-Bis[(trimethylsilyl)oxy]pregn-4-ene-3,20-dione bis(O-methyloxime); Protected Cortisone Bis-O-Methyloxime; TMS-protected Cortisone Dioxime Derivative
EINECS	Contact for details

Quality Control

Our Pregn-4-Ene-3,20-Dione, 11,17-Bis[(Trimethylsilyl)Oxy]-, Bis(o-Methylo Xime), (11Beta)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are available for every lot. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.