Description

Di(n-Succinimidyl) Oxalate is a high-purity, bifunctional N-hydroxysuccinimide (NHS) ester crosslinking reagent. This compound is essential for creating stable amide bonds between primary amines, facilitating the conjugation of biomolecules such as proteins, peptides, and antibodies. It is a critical tool for researchers and manufacturers in the pharmaceutical development, bioconjugation, and diagnostic kit production sectors, where reliable and efficient crosslinking is paramount.

Application

• Bioconjugation and Protein Crosslinking: Primary reagent for covalently linking proteins, peptides, or antibodies to other molecules, surfaces, or carriers.
• Immunoassay Development: Used in the preparation of enzyme-antibody conjugates for ELISA and other diagnostic assays.
• Affinity Chromatography Ligand Immobilization: Facilitates the stable attachment of proteins or other ligands to chromatographic resins.
• Drug Delivery System Fabrication: Employed in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutic constructs.
• Biomaterial and Surface Functionalization: Enables the modification of polymers, nanoparticles, or sensor surfaces with bioactive molecules.
• Research and Development: A key synthetic tool in chemical biology and medicinal chemistry for probing biological interactions.

Basic Information

Product Name	Di(n-Succinimidyl) Oxalate
CAS No.	57296-03-4
Molecular Formula	C10H8N2O8
Molecular Weight	284.18 g/mol
Synonyms	Disuccinimidyl Oxalate; Oxalic Acid Bis(2,5-dioxopyrrolidin-1-yl) Ester; N,N'-Disuccinimidyl Oxalate; DSO; NSC 334368; Bis(N-succinimidyl) Oxalate; Oxalyl Di(N-succinimide)
EINECS	Contact for details

Quality Control

Our Di(n-Succinimidyl) Oxalate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.