Description

(17R)-17-(Acetyloxy)-3β-Fluoro-5-Hydroxypregn-20-Yn-6-One CAS NO 57194-88-4 is a high-purity fluorinated pregnane derivative, a key advanced intermediate in modern pharmaceutical synthesis. This compound is valued for its specific stereochemistry and functional groups, which enable precise chemical transformations in the development of active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel steroid-based drugs and hormonal agents.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• Process Chemistry: Serves as a key intermediate in scaling up and optimizing synthetic routes for API manufacturing under GMP conditions.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical laboratories.

Basic Information

Product Name	(17R)-17-(Acetyloxy)-3β-Fluoro-5-Hydroxypregn-20-Yn-6-One
CAS No.	57194-88-4
Molecular Formula	C23H31FO4
Molecular Weight	390.49 g/mol
Synonyms	3β-Fluoro-5-hydroxy-17α-acetoxypregn-20-yn-6-one; (17R)-17-(Acetyloxy)-3β-fluoro-5-hydroxypregn-20-yn-6-one; 3β-Fluoro-5,17α-dihydroxypregn-20-yn-6-one 17-acetate; 17α-Acetoxy-3β-fluoro-5-hydroxypregn-20-yn-6-one; 3-Fluoro-5-hydroxy-17α-acetoxypregn-20-yn-6-one; Pregn-20-yn-6-one, 17-(acetyloxy)-3-fluoro-5-hydroxy-, (3β,17R)-
EINECS	Contact for details

Quality Control

Our (17R)-17-(Acetyloxy)-3β-Fluoro-5-Hydroxypregn-20-Yn-6-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical R&D and intermediate use. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials such as strong alkalis and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.