Description

n-Succinimidyl 3-(Bromoacetamido)Propionate is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive bromoacetamide group. This compound matters for its critical role in the site-specific conjugation of biomolecules, enabling the creation of stable thioether linkages essential for advanced research and diagnostics. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and the preparation of protein and peptide conjugates for therapeutic and diagnostic applications.

Application

• Site-specific bioconjugation and crosslinking of proteins, peptides, and antibodies.
• Synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Preparation of enzyme conjugates and immobilized ligands for assay development.
• Functionalization of nanoparticles and surfaces with biomolecules for biosensing.
• Introduction of reactive handles onto biomolecules for further chemical modification.
• Research tool in chemical biology for studying protein-protein interactions and structure.

Basic Information

Product Name	n-Succinimidyl 3-(Bromoacetamido)Propionate
CAS No.	57159-62-3
Molecular Formula	C9H11BrN2O5
Molecular Weight	307.10 g/mol
Synonyms	SBAP; 3-(Bromoacetamido)propionic Acid N-Succinimidyl Ester; N-Succinimidyl 3-(Bromoacetamido)Propanoate; Bromoacetamidopropionic Acid NHS Ester; SBP; 3-[(Bromoacetyl)amino]propanoic Acid 2,5-Dioxopyrrolidin-1-yl Ester; 1-[(3-Bromoacetamidopropanoyl)oxy]pyrrolidine-2,5-dione; NHS-Bromoacetate Propionate
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 3-(Bromoacetamido)Propionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive bioconjugation work. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.