Description

1,25-Dihydroxy-Previtamin D(3) is a key intermediate metabolite in the vitamin D biosynthetic pathway, representing a crucial stage in the formation of the active hormonal form. This compound is of significant interest for research and development in the fields of endocrinology, bone metabolism, and pharmaceutical synthesis. It is primarily utilized by research institutions, pharmaceutical developers, and manufacturers of high-purity biochemical standards.

Application

• Biochemical Research: Critical intermediate for studying the metabolic activation pathway of vitamin D and its physiological regulation.
• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and assay development of vitamin D-related pharmaceuticals.
• Metabolic Pathway Analysis: Employed in in vitro and in vivo studies to elucidate the conversion steps from previtamin D3 to calcitriol.
• Academic & Clinical Studies: Essential for investigating the role of vitamin D metabolism in diseases such as osteoporosis, renal failure, and certain cancers.
• Synthetic Chemistry: Serves as a high-purity starting material or intermediate for the synthesis of labeled vitamin D analogs (e.g., deuterated or radiolabeled compounds) for tracer studies.

Basic Information

Product Name	1,25-Dihydroxy-Previtamin D(3)
CAS No.	57102-09-7
Molecular Formula	C27H44O3
Molecular Weight	416.64 g/mol
Synonyms	1,25-Dihydroxyprecholecalciferol; Precalcitriol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol; 1α,25-Dihydroxyprevitamin D3; 1α,25-Dihydroxy-9,10-secocholesta-5(10),6,8-trien-3β-ol; 1,25(OH)2-PreD3
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-Previtamin D(3) is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and related substance profiles. We adhere to relevant guidelines for research chemicals and can provide material suitable for use as an in-house reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to minimize oxidation and thermal degradation. For long-term storage, keep desiccated to protect against moisture. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.