Description

Boc-Thr(Bzl)-Onp is a protected amino acid derivative, specifically a Boc-protected threonine benzyl ester activated with an o-nitrophenyl (Onp) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient formation of peptide bonds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester, it serves as a key intermediate for the sequential coupling of amino acids to construct specific peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Employed to introduce threonine residues with orthogonal protecting groups into larger biomolecules or synthetic scaffolds.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: Fundamental studies in organic chemistry, biochemistry, and medicinal chemistry exploring peptide structure and function.
• Custom Peptide Service Providers: Essential raw material for companies offering bespoke peptide synthesis services.

Basic Information

Product Name	Boc-Thr(Bzl)-Onp
CAS No.	56618-45-2
Molecular Formula	C₂₁H₂₄N₂O₇
Molecular Weight	416.43 g/mol
Synonyms	Boc-Thr(Bzl)-ONp; (2S,3R)-3-Benzyloxy-2-[(tert-butoxycarbonyl)amino]butanoic acid 4-nitrophenyl ester; tert-Butyloxycarbonyl-O-benzyl-L-threonine p-nitrophenyl ester; Boc-O-benzyl-L-threonine p-nitrophenyl ester; Boc-L-Thr(Bzl)-ONp; N-(tert-Butoxycarbonyl)-O-benzyl-L-threonine 4-nitrophenyl ester; Boc-Thr(OBzl)-ONp; N-Boc-O-benzylthreonine p-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Boc-Thr(Bzl)-Onp is manufactured under strict quality control protocols to ensure high chemical purity and consistency, essential for reproducible results in sensitive synthetic applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	[α]²⁰D = Contact for details
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.