Description

1H-Benzotriazol-1-Yloxytris(Dimethylamino)Phosphonium Hexafluorophosphate is a highly reactive phosphonium salt primarily used as a peptide coupling reagent. This compound matters because it offers high efficiency and minimal racemization in the synthesis of sensitive amide bonds, a critical step in pharmaceutical and biotech research. It is an essential reagent for researchers and manufacturers in peptide synthesis, medicinal chemistry, and the production of complex organic molecules.

Application

• Peptide Synthesis: As a powerful coupling agent (BOP-type reagent) for forming amide bonds with high yield and low epimerization.
• Medicinal Chemistry & Drug Discovery: For the efficient synthesis of peptide-based drug candidates, peptidomimetics, and other bioactive compounds.
• Solid-Phase Peptide Synthesis (SPPS): Used in automated and manual SPPS protocols for the production of peptides.
• Organic Synthesis: Facilitating challenging condensation reactions and the synthesis of complex natural products.
• Bioconjugation: For linking peptides to other molecules, proteins, or surfaces in biotech applications.
• Academic & Industrial R&D: A key reagent in laboratories focused on developing new synthetic methodologies.

Basic Information

Product Name	1H-Benzotriazol-1-Yloxytris(Dimethylamino)Phosphonium Hexafluorophosphate
CAS No.	56602-33-6
Molecular Formula	C13H22F6N6OP2
Molecular Weight	470.29 g/mol
Synonyms	Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate; BOP Reagent; Castro's Reagent; (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; BOP; Coupling Reagent BOP; 1H-1,2,3-Benzotriazol-1-ol, 1-[[tris(dimethylamino)phosphoranylidene]amino]-, hexafluorophosphate(1-)
EINECS	Contact for details

Quality Control

Our 1H-Benzotriazol-1-Yloxytris(Dimethylamino)Phosphonium Hexafluorophosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards required for research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.