Description

Benzotriazol-1-Yloxy-Tris(Dimethylamino)Phosphonium CAS NO 56602-32-5 is a highly reactive phosphonium salt primarily used as a peptide coupling reagent. Its core value lies in its ability to facilitate efficient amide bond formation with minimal racemization, which is critical for the synthesis of complex peptides and other sensitive organic molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced organic synthesis sectors who require high-purity, reliable reagents for constructing peptide backbones and other amide linkages.

Application

• Peptide Synthesis: As a key coupling reagent (BOP reagent) for solid-phase and solution-phase peptide synthesis, enabling the formation of amide bonds between amino acids.
• Pharmaceutical Intermediates: In the production of active pharmaceutical ingredients (APIs) and complex drug candidates that contain peptide structures.
• Bioconjugation: For linking peptides to other molecules, such as proteins, dyes, or polymers, in drug delivery system development and diagnostic probe creation.
• Organic Synthesis: As a versatile reagent for the synthesis of amides, esters, and other derivatives from carboxylic acids under mild conditions.
• Research & Development: A staple tool in academic and industrial R&D laboratories for exploring new synthetic methodologies and constructing novel biomimetic compounds.
• Protecting Group Chemistry: Used in multi-step synthetic sequences where selective amide formation is required in the presence of other functional groups.

Basic Information

Item	Details
Product Name	Benzotriazol-1-Yloxy-Tris(Dimethylamino)Phosphonium
CAS No.	56602-32-5
Molecular Formula	C15H27N6OP
Molecular Weight	338.39 g/mol
Synonyms	BOP Reagent; Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (common salt form); (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium; Castro's Reagent; BOP; Coupling Reagent BOP; Tris(dimethylamino)(1H-benzotriazol-1-yloxy)phosphonium
EINECS	Contact for details

Quality Control

Our Benzotriazol-1-Yloxy-Tris(Dimethylamino)Phosphonium is manufactured under strict quality management systems to ensure batch-to-batch consistency and high performance. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to meet the exacting standards required for sensitive synthetic applications. Certificates of Analysis (COA) with full specification data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to maintain stability and reactivity. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.